In particular, significant dysregulation in controls vs definite AD was observed for ARL1, ATXN10, CAMK2B, CAPNS1, EFNB3, GNB1, KCNMA1, KLC1, MAPRE1, MAPRE3, MOB4, and TREM2. The tissue specificity of the differential expression results (i.e., dysregulation seen in parahippocampal gyrus but not in the temporal cortex as a whole) can be interpreted as a reflection of the use of a tissue-specific gene interaction network (hippocampus) and of the high spatial variability in brain transcriptomic profiles. Here, TREM2 is linked to Alzheimer disease.