Furthermore, the local gene-interaction neighborhood of CAMK2B, which was identified by NETPAGE, shows a series of compelling dementia risk genes (Fig 3C): key players in familial AD (APP, PSEN2), genes in which rare variation is linked to sporadic AD (PLD3, ABCA7, SORL1; [49–51]), GWAS genes (APOE, CLU, BIN1, PICALM), genes identified through multivariate imaging genetics studies (TRIB3; [52]) and genes causal for other neurodegenerative diseases (MAPT, GRN, HTT, OTUD4 [53]). Here, APP is linked to neurodegenerative disease.