CYP2C19 and Ito hypomelanosis: IPA was higher at all time points except at baseline in patients treated with ticagrelor/aspirin therapy compared with those treated with clopidogrel/aspirin therapy in both carriers and non-carriers of CYP2C19 LOF alleles (all p<0.001 for 2h, 24h, 7d and 90d-IPA, respectively; Table 4).