It has been reported that oncogenic RBPs such as GTPBP4, PRKDC, RAN, SF3B4, SMG5, SPATS2, TAF9, and THOC5 promoted HCC cell proliferation, apoptosis, migration and invasion, which led to tumorigenesis and poor overall survival. The gene discussed is GTPBP4; the disease is hepatocellular carcinoma.