Importantly, we did not observe any alterations of areas syntenic to chromosomal regions reported in human NB, such as 17q, 11q or 1p or in either Tert or Atrx. Nor did we detect any Alk mutations, potentially activating or otherwise, in NB arising in Rosa26_Alkal2;Th‐MYCN animals. Here, ALK is linked to neuroblastoma.