While this number of responding genes was an order of magnitude lower as compared to the Alk‐F1178S;Th‐MYCN tumours (381 differentially expressed genes), 52.5% (21/40) differentially expressed genes in Rosa26_Alkal2;Th‐MYCN overlapped with the response in Alk‐F1178S;Th‐MYCN tumours (P = 6.9e‐27, Fisher's exact test; Fig 5D). Here, MYCN is linked to neoplasm.