Considering that endogenous endometrial HOXA10 expression directly regulates endometrial expression of important factors for embryo implantation, including β3-integrin and the divergent homeobox gene emx2/EMX2, hypermethylation of hoxa10 at the peri-implantation period may predispose patients to epigenetically determined infertility [153]. The gene discussed is HOXA10; the disease is Infertility.