Here, a novel combination of photothermal therapy facilitated by a tumor targeted singe-walled carbon nanotube (SWCNT) bioconjugate and anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) checkpoint inhibition is studied for treating metastatic breast cancer in an orthotopic murine model. Here, CTLA4 is linked to neoplasm.