In the DENV-AG129 mouse-infection model where mice survive the acute viremia, circulating FB protein levels are unchanged while FH protein was reduced at day 4 p.i. In a more severe dengue model with ADE of infection, the mice succumb to disease at day 6 p.i. concomitant with viremia, and this is associated with an early increase in FB (day 3 p.i.)while FH levels significantly decrease. This evidence concerns the gene FH and dengue disease.