Although it has been reported that STAT3 inhibitor enhanced the sensitivity of HCC cells with high expression of p‐STAT3 to sorafenib in vitro, and STAT3 activation in malignant cells depends on signals produced by neighbouring cells,13 the effect and mechanism of constitutive STAT3 activation has not been fully understood in vivo.11, 19. This evidence concerns the gene STAT3 and hepatocellular carcinoma.