However, constitutively activated STAT3 was detected in approximately 60% of human HCC specimens and phosphorylated STAT3 (p‐STAT3) positive tumours were more aggressive11 In addition, activated STAT3 of HCC impairs sorafenib‐induced cell death by promoting anti‐apoptotic protein or cancer stem cell markers.17, 18. The gene discussed is STAT3; the disease is hepatocellular carcinoma.