Although PSMA-targeted imaging demonstrates improved sensitivity and specificity in detecting bone metastases compared to traditional imaging modalities, such as bone scintigraphy, CT, and MRI, in patients with primary intermediate or high-risk PC, PSMA-ligand uptake can appear in other benign as well as malignant osseous lesions [19, 23]. This evidence concerns the gene FOLH1 and pachyonychia congenita.