When comparing anti-PD-1/PD-L1 mAbs plus chemotherapy and chemotherapy, there was a significant increase in the RR of all-grade increased blood creatinine (RR =1.88, 95% CI: 1.24–2.86, P = 0.003) and AKI (RR =3.35, 95% CI: 1.48–7.60, P = 0.004; Fig. 3). The gene discussed is CD274; the disease is acute kidney injury.