CCR2 and ischemic stroke: Although the monocyte-monocyte conversion by the reprogramming of classical monocytes was not found in the model of ischemic stroke, it is worth mentioning that (1) a cytokine-dependent transition from classical monocytes to reparative macrophages plays a vital role in temporal and spatial events for the endogenous restoration and (2) these macrophages mainly acting on neuroinflammation do not originate from resident microglia, but infiltrating blood circulating CCR2(+) monocytes following ischemic stroke.