A ZNTRT × ENERGY effect was noted for plasma IGF-1 concentrations (P = 0.04) where CON LE was greater than CON HE and INZN HE (P ≤ 0.02) and ZNBLD HE was greater than CON HE (P = 0.04; Figure 1). This evidence concerns the gene IGF1 and hereditary elliptocytosis.