In particular, collagen VI is highly expressed in adipose tissue and plays a key role in the fibrosis associated with obesity, thus its degradation, promoted by decorin, may counteract the development of adipose tissue fibrosis and so it could be leveraged for therapeutic purposes (Kuo et al., 1997) (Figure 10). The gene discussed is DCN; the disease is obesity due to melanocortin 4 receptor deficiency.