TGFB1 and Hepatic fibrosis: In addition, the Wnt/β-catenin pathway, through its crosstalk with the TGF-β signaling, can upregulate myofibroblasts formation and their consequent fibrotic tissue deposition (Yanagida et al., 2011) and inhibition of the mTOR pathway by rapamycin attenuates hepatic fibrosis in rat models (Bridle et al., 2009).