Hypoxia-inducible factor (HIF-1α) and Lysyl oxidases (LOXs) are responsible for the increased EMT (Trackman, 2016) and ablation of HIF-1α and inhibition of LOXs could ameliorate renal fibrosis (Erler et al., 2006), making LOXs and HIF-1α possible targets for an anti-EMT and anti-fibrosis therapy in kidney. The gene discussed is HIF1A; the disease is fibrosis.