In addition, the EMT has been proposed as a source of myofibroblast also in SSc (Gillespie et al., 2011; Nikitorowicz-Buniak et al., 2015) and EMT-related pathways, such as the Wnt or TGF-β induced pathways, have been shown to be involved in scleroderma (Lee et al., 2020). Here, TGFB1 is linked to systemic sclerosis.