LGALS1 and age-related macular degeneration: Flanders (2004) and Singh et al. (2012). A study carried out on murine corneal progenitor cells, showed the induction of irreversible EMT following cell senescence induced by TGF-β through the Smad pathway (Kawakita et al., 2013). More recently, in a murine model, it has been demonstrated the role of galectin-1 (LGALS1) as a promoter of the TGF-β receptor signaling, and the overexpression of LGALS1 results in EMT-induced subretinal fibrosis in patients affected by age-related macular degeneration (AMD) (Wu D. et al., 2019).