Moreover, the findings of a study focused on morphea, a form of localized scleroderma, suggest the involvement of EMT also in this type of skin disease, on the basis of the expression level of fibrosis (TGF-β1, αSMA and fibronectin) and EMT (Snail1 and E-cadherin) markers, although only the EMT markers were found reduced in this localized scleroderma (Takahashi et al., 2013). This evidence concerns the gene ACTA1 and localized scleroderma.