LEP and obesity due to melanocortin 4 receptor deficiency: However, obesity had no effect on adiponectin and resistin secretion in postmenopausal women with OP, so leptin was the only one of the adipokines studied to be considered as a protective factor for bone tissue in postmenopausal women (Pasco et al., 2001; Glogowska-Szelag et al., 2019).