NLRP3 inflammasome activation has been implicated in the initiation or development of different inflammatory diseases such as gout (Kingsbury et al., 2011), myocardial infarction (Jalil and Ghazi, 2020), and diabetes (Wan et al., 2019), obesity (Sokolova et al., 2019), glomerular injury (Li et al., 2017), and atherosclerosis (Zhuang et al., 2019). This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.