NLRP3 inflammasome activation has been implicated in the initiation or development of different inflammatory diseases such as gout (Kingsbury et al., 2011), myocardial infarction (Jalil and Ghazi, 2020), and diabetes (Wan et al., 2019), obesity (Sokolova et al., 2019), glomerular injury (Li et al., 2017), and atherosclerosis (Zhuang et al., 2019). The gene discussed is NLRP3; the disease is atherosclerosis.