TGFB1 and cancer: The cancer immunotherapy is adversely influenced by the immunosuppressive nature of TME because of the presence of TAMs, regulatory T cells (Tregs), and MDSCs, together with enzymes and cytokines (TGF-β, indoleamine 2,3-dioxygenase (IDO), IL-10, etc.)(Quail and Joyce, 2013; Musetti and Huang, 2018).