They also loaded oncogenic human papillomavirus 16 (HPV16) antigen, E6/E7 to Clec9A- TNE and demonstrated that HPV16 E6/E7- Clec9A- TNE significantly inhibited tumor growth, stimulated potent antigen specific IFN-γ responses and enhanced the survival of the mice. The gene discussed is IFNG; the disease is neoplasm.