In chronic lymphocytic leukemia (CLL) several components of the WNT pathway have been found deregulated: WNT3, WNT5B, WNT6, WNT10A, WNT14, and WNT16, as well as the WNT receptor FZD3, are highly expressed in CLL when compared with normal B cells (51–53). This evidence concerns the gene FZD3 and B-cell chronic lymphocytic leukemia.