ROR2 and cancer: We also demonstrated, using in vitro and ex vivo 3D-culture systems, that ROR2 exerts a pivotal role in the adhesion of cancer cells to the microenvironment, mainly through the PI3K-AKT pathway, and that genetic and pharmacological inhibition of the AKT pathway is able to reduce ROR2-induced adhesion of malignant cells to bone marrow components (46).