Our study showed that DSF/Cu not only inhibited glycolysis and OXPHOS by repressing OCR and ECAR in MKN-45 and BGC-823 cells but also decreased the levels of Fzd7, β-catenin, C-myc, and Cyclin D1 in MKN-45 and BGC-823 cells, indicating the deregulation of Wnt/β-catenin signaling pathway in GC. The gene discussed is FZD7; the disease is gastric cancer.