Among them, ovulatory dysfunction, menstrual irregularities, infertility, hyperandrogenism, increased insulin level, obesity, obstructive sleep apnea, nonalcoholic fatty liver disease, eating and mood disorders, cardiovascular disease (CVD) and an increased risk of type 2 diabetes mellitus (T2DM) are significant factors [3,4]. However, the most common presenting problem observed in PCOS is menstrual cycle disturbances (oligo/amenorrhea), hirsutism, infertility, dyslipidemia and metabolic disturbances due to insulin resistance (IR) [5]. The gene discussed is INS; the disease is type 2 diabetes mellitus.