To the best of our knowledge, other studies exploring the effect of periodontal treatment on adipokines have focused only on visfatin.24,29 Bearing this in mind, the present study was designed to assess salivary levels of visfatin, chemerin, and progranulin in diabetic patients with periodontitis and determine the effect of non-surgical therapy on salivary levels of these three adipokines. The gene discussed is RARRES2; the disease is periodontitis.