Visfatin, which is also known as pre-B cell colony enhancing factor (PBEF)/nicotinamide phosphoribosyltransferase (NAMPT), is an adipokine produced in adipose tissue, macrophages, granulocytes, and monocytes.26 This pleiotropic mediator has antiapoptotic activity and activates B cells to exert immunoregulatory and proinflammatory effects in inflammation.27 According to Pradeep et al12,28 visfatin levels in the saliva, serum, and gingival crevicular fluid (GCF) increase in periodontitis compared to healthy individuals. This evidence concerns the gene NAMPT and periodontitis.