Proliferating cancer cells generally require higher uptake of cholesterol with high expression of LDLR because of the need for plasma membrane construction and an extra energy source to sustain growth (Furuya et al., 2016; Haeffner et al., 1984; Vitols et al., 1984;Vitols et al., 1996; Zhou et al., 2017). Here, LDLR is linked to cancer.