APP and Alzheimer disease: Likewise, peripheral blood EVs enriched for neuronal origin from pre‐symptomatic AD patients carry increased amounts of AD pathogenic proteins including P‐S396‐tau, P‐T181‐tau, APP, Aβ1‐42 (Fiandaca et al., 2015; Kapogiannis et al., 2019; Rajendran et al., 2006; Sharples et al., 2008), insulin receptor substrate‐1 (Kapogiannis et al., 2019), lysosomal proteins (Goetzl et al., 2015), neuronal survival factors (Goetzl et al., 2015) and pre‐synaptic proteins (Goetzl et al., 2018) compared cognitively normal controls.