We speculated that type I collagen serves as the 3D skeleton for biomechanical signals, and fibrin analog FN uses membrane-spanning receptor protein integrin αvβ3 to transduce the pro-survival signal induced by biomechanical force in the tumor microenvironment, explaining the role of collagen and FN in glioma cell culture and tumor growth. Here, FN1 is linked to central nervous system cancer.