Many inflammatory mediators are reportedly involved in the pathogenesis of OA 60 thus, we used a 24-h stimulation with IL-1β (and OSM (oncostatin M) in HCs to represent the arthritis group (GSM2306268, GSM2306272, and GSM2306264), the phenotypes of which were much similar to those of arthritic chondrocytes, versus the negative control group (GSM2306261, GSM2306265, and GSM2306269). This evidence concerns the gene IL1B and arthritic joint disease.