MAP3K8 is known to regulate downstream signaling pathways such as MEK/ERK MAPK, mTOR, NF-κB, and p38 MAPK in many diseases, including tumorigenesis in mice 65, rabies virus infection 66 and a model of chronic myeloid leukemia 67. The gene discussed is NFKB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.