In contrast, inhibition of mtROS production with MT significantly ameliorated renal dysfunction, as indicated by decreased levels of serum CREA/UREAL, renal Kim-1, tubular apoptosis/necrosis, and renal inflammatory response in MT-treated IRI-AKI mice compared with untreated IRI-AKI mice (Figure 1A-D). This evidence concerns the gene HAVCR1 and acute kidney injury.