In our study, we uncovered a mechanism by which EZH2 directly occupies the promoter region of CHK1 and induces its activation in epithelial ovarian cancer, which is consistent with a recent study showing that EZH2 functioned in activating NOTCH1 signaling by directly binding to the NOTCH1 promoter in breast cancer 37. The gene discussed is CHEK1; the disease is breast carcinoma.