For instance, Foxo3 circRNA inhibits cell cycle progression via forming ternary complexes with p21 and CDK2 30, ANRIL circRNA modulates ribosomal RNA (rRNA) maturation and atherosclerosis through its binding with pescadillo homologue 1 (PES1), an essential 60S-preribosomal assembly factor 31 and circACC1 has been shown that it can directly binds to both AMPKβ and γ Subunits, facilitating AMPK holoenzyme assembly, stability and activity 32. Here, PRKAB1 is linked to atherosclerosis.