Taken together, we conclude that simvastatin prevents TAC-induced pathological cardiac remodeling via direct repression of TGFβ1 through induction of EC-Klf2 or by Klf2-Foxp1 transcription factor network to further retard the progression of cardiac dysfunction to HF, which was shown in the schematic Figure 7G. The gene discussed is TGFB1; the disease is hydrops fetalis.