The clarification of the novel cardioprotective mechanism of simvastatin, the anti-remodeling effects of statin is mediated through EC-KLF2 direct repression of TGFβ1, or through the Klf2-Foxp1-TGFβ1 pathway, might provide an opportunity for simvastatin as a future intervention for prevention of HF. The gene discussed is KLF2; the disease is hydrops fetalis.