Our study confirmed the novel protective effects of simvastatin on TAC-induced pathological cardiac remodeling through regulation of Klf2-TGFβ1 or KLF2-Foxp1-TGFβ1 signal pathway in cardiac microvasculature ECs in addition to the previous reports of simvastatin's pleiotropic effects, which might provide an opportunity for simvastatin as a future prevention for HF. Here, TGFB1 is linked to hydrops fetalis.