Hyde cytokine, IL-34 can be considered a good theraupeutic target against a wide range of diseases, from virus infections such as HCV or HBV, to autoimmune diseases such as RA, systemic sclerosis, systemic lupus erythematous, Sjogren's syndrome 139 and inflammatory bowel diseases, to cancer-like osteosarcoma, lung cancers, melanoma, colorectal cancer, ovarian tumors, prostate cancer 97 and hepatocellular carcinoma 100,101. This evidence concerns the gene IL34 and Sjogren syndrome.