ALB and neoplasm: To improve the transcytosis of lapatinib across the BBB, Wan et al. relied on enhanced EPR effect plus attraction of HSA NPs by SPARC (secreted protein acidic and rich in cysteine), as well as on beneficial properties of HSA that include preferential tumor uptake and binding to 60-kDa glycoprotein receptor on vascular endothelial cells 89.