Conditions of PTEN mutations include Cowden syndrome 1 (Pilarski, 2009), PTEN hamartoma tumor syndrome (Mester and Charis, 2016), Cutaneous melanoma (Bittner et al., 2000; Balch et al., 2001) etc. A total of 44 mutations, with only one negative (benign) sample, made data enhancement indispensable. This evidence concerns the gene PTEN and cutaneous melanoma.