MAPT and early-onset autosomal dominant Alzheimer disease: Moreover, aberrant tau exon 10 splicing has been implicated in a range of sporadic tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system tauopathy with dementia (MSTD), and argyrophilic grain disease (AGD), as well as some forms of Alzheimer’s disease (Andreadis, 2006).