MAPT and tauopathy: DDX5/RNA helicase p68 is reported to regulate tau exon 10 splicing by modulating the stem-loop structure at the 5′ splice site (Forman et al., 2004), and disruption of the regulation of tau exon 10 splicing plays an important role in the pathogenesis of tauopathy (Forman et al., 2004).