Single-center retrospective review of medical records of acromegaly patients to explore the prevalence of diagnosed autoimmune diseases.<h4>Results</h4>We report a Caucasian woman in her 50's with a serologically (anti-SSA/Ro, anti-MPO-ANCA antibodies) and histologically confirmed diagnosis of symptomatic SS and MPA. This evidence concerns the gene MPO and acromegaly.