Importantly, they also showed that pan-IFNα (α1, α4, α5, α11, and α13) mAb blockade, but not IFNβ blockade, was able to recapitulate the anti-IFNAR1 phenotype, demonstrating a distinct role for IFNα subtypes in promoting pathogenesis in the Rip-LCMV T1D model. This evidence concerns the gene IFNB1 and type 1 diabetes mellitus.