Additionally, non-obese diabetic (NOD) mice, a common model for T1D, showed elevated IFN-inducible transcripts in the pancreatic islets prior to disease onset, and treatment of young NOD mice with anti-IFNAR1 mAb delayed the onset and decreased the occurrence of T1D (298, 299). This evidence concerns the gene IFNAR1 and type 1 diabetes mellitus.