CD8A and infection: As discussed above, LCMV-Cl-13 infection causes persistent infection in certain mouse strains (C57BL/6, BALB/C, C3H, or SWR/J); however, LCMV-Cl-13 infection of other strains (NZB, SJL/J, PL/J, NZO, or FVB/N mice) causes type I IFN- and CD8 T cell-dependent severe vascular leakage and death by about 6–8 days post infection (dpi) (81, 82, 106, 107).