SIGLEC1 and central nervous system cancer: Especially the ability to predict the outcomes of LGG makes the model a more comprehensive evaluation method, addition with the SIGLEC1 and FPR3 could be two novel biomarkers to estimate grade and IDH status of glioma and six genes are correlated with immune checkpoint, the model will be helping for the diagnosis and treatment of glioma, in particular with respect to evaluate LGG.