A multiplex nanoparticle assembled by a NIR photosensitizer named IR780 and an IDO inhibitor named NLG919 enhanced accumulation in the tumor site via passive targeting, increased the infiltration and differentiation of T cells into CD8+ T cells, suppressed the tumor margin beyond the border of effective photothermal therapy and strengthened the immune response to inhibit the distal tumor (78).The assembly of gold nanoparticles into fluid liposomes produced photothermal sensors that have NIR-I and NIR-II biological windows and respond to different absorptions of red light. This evidence concerns the gene CD8A and neoplasm.