FAS and neoplasm: In this scenario, it would be best to preserve lesser-differentiated populations of T cells by blocking CD95-mediated T-cell death and differentiation in vivo, which is precedented in a murine-human xenograft model of CAR-T adoptive immunotherapy; CAR-T cells transduced with a recombinant Fas receptor lacking an intracellular signaling domain were substantially more capable of inducing durable tumor responses and showed increased in vivo persistence, presumably by virtue of their attenuated differentiation and death (54).