CD4 and acute respiratory distress syndrome: Fagone et al. describe a transcriptomic profile in which Akt signaling was associated with disease progression (40), and Somanath discusses a similar rationale of modulating immune-mediated inflammation: that Akt inhibition is justified on the basis of an anti-inflammatory effect exerted by CD4+ T cells that may differentiate into Effector T regulatory cells in the ARDS lung (41).