When taking this finding from Yang et al. of a diminished proportion of Naïve CD4+ and CD8+ T cells post- Covid-19 (53) along with the finding from Moderbacher, et al. that naïve CD8+ T cells are associated with lesser disease severity (12), we must consider the consequences of reinfection if the pool of naïve T cells significantly diminishes after infection and outcomes are influenced by the presence of naïve CD8+ T cells. The gene discussed is CD8A; the disease is infection.