NT5C2 is associated with disorders characterized by psychiatric and psychomotor disturbances such as hereditary spastic paraplegias (HSP) (Garcia-Gil et al., 2018), schizophrenia (Cross-Disorder Group of the Psychiatric Genomics, 2013; Duarte et al., 2016; Duarte et al., 2019) and Parkinson disease. Here, NT5C2 is linked to hereditary spastic paraplegia.