Since vascular damage is also a pathogenic factor of AD, BM-MSCs can promote angiogenesis in the AD brain by secreting vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), FGF-2, and Ang-1 (Gallina et al., 2015), and thus favor the cognitive and behavioral recovery (Garcia et al., 2014). Here, EGF is linked to Alzheimer disease.