CLMP and temporal lobe epilepsy: Lastly, because Clmp deletion leads to increased miniature excitatory post-synaptic currents in CA3 pyramidal cells and alters the kinetics of AMPAR- and KAR-mediated evoked excitatory synaptic transmission, we tested whether Clmp−/− mice display altered susceptibility to seizures induced by kainate (a KAR agonist and a partial AMPAR agonist at MF-CA3 synapses), modeling temporal lobe epilepsy (Nadler, 1981; Engel, 1996; Ben-Ari and Cossart, 2000).