Finally, other receptors related to endocannabinoid signaling, such as the transient receptor potential vanilloid 1 (TRPV1) and the GPR55, both activated by anandamide and associated with anticonvulsant effects (Van Der Stelt et al., 2005; Ryberg et al., 2007; Lazarini-Lopes et al., 2020), could be partially involved with CB1R modulation and should be further investigated in the genetic models of epilepsies. Here, CNR1 is linked to epilepsy.