MAPT and Alzheimer disease: MiR-125b is one of the highly abundant microRNAs in the brain, and emerging evidence has implicated its involvement in multiple aspects of AD pathogenesis such as neuron apoptosis and tau phosphorylation (Cogswell et al., 2008; Banzhaf-Strathmann et al., 2014; Ma et al., 2017; Jin et al., 2018).