Regarding Si-CDK5, it inhibited TNF-α (Figure 12A), IL-1β (Figure 12B), and IL-6 (Figure 12C) levels in NC primary neuron AD model, while Si-CDK5 only attenuated IL-6 level (Figure 12C) but not TNF-α (Figure 12A) or IL-1β (Figure 12B) level in FOXQ1 siRNA–treated primary neuron AD model. The gene discussed is IL1B; the disease is Alzheimer disease.