In terms of Si-CDK5, it only decreased IL-1β level (Figure 12E) but not TNF-α (Figure 12D) or IL-6 (Figure 12F) level in NC PC-12 cellular AD model; meanwhile, Si-CDK5 repressed all TNF-α (Figure 12D), IL-1β (Figure 12E), and IL-6 (Figure 12F) levels in FOXQ1 siRNA–treated PC-12 cellular AD model. This evidence concerns the gene IL1B and Alzheimer disease.