CDK5 and Alzheimer disease: In both primary neurons (Supplementary Figures 1A–F, 2A–C) and NGF-stimulated PC-12 cells (Supplementary Figures 1G–L, 2D–F), FOXQ1 expression and neurite outgrowth were decreased, while PTGS2 and CDK5 expressions, cell apoptosis, and inflammation (including TNF-α, IL-1β, and IL-6) were increased in AD models compared with normal cells.