This was likely to be explained by miR-125b inhibition itself and greatly promoted neurite outgrowth and repressed inflammation, and CDK5 inhibition could only enhance neurite outgrowth and inhibited inflammation to some extent; thus, the effect of CDK5 inhibition on modulating miR-125b inhibition–mediated neurite outgrowth and inhibited inflammation was not obvious in AD. This evidence concerns the gene CDK5 and Alzheimer disease.