MAPT and Alzheimer disease: MicroRNA-125b (MiR-125b), one of the most abundant miRNAs in the brain, is closely linked to the regulation of tau phosphorylation, neuroinflammation, and neuron apoptosis by the modulation of inflammatory factors and oxidative stress, which is implicated in the pathogenesis of AD (Banzhaf-Strathmann et al., 2014; Graham et al., 2017; Jin et al., 2018; Ma et al., 2019).