IL1B and Alzheimer disease: In NC or miR-125b inhibitor–treated primary neuron AD model (Figures 7A–F), as well as in NC or miR-125b inhibitor–treated PC-12 cellular AD model (Figures 7G–L), Si-PTGS2 repressed PTGS2 expression and cell apoptosis but facilitated neurite outgrowth (Figures 7A–L); meanwhile, Si-PTGS2 also reduced TNF-α, IL-1β, and IL-6 levels (Figures 8A–F).