BECN1 and Alzheimer disease: In addition, EA at GV20 and BL23 increased the autophagy-related protein Beclin-1 level and LC3 II/LC3 I ratio, but decreased Aβ plaque and neuronal apoptosis in the hippocampal CA1 region (Guo et al., 2016), suggesting that modulation of autophagy modulators by EA is involved in the rescue of cognitive dysfunction in AD model animals.