IL12RB1 and systemic lupus erythematosus: Several studies demonstrated that IL-12 levels are increased in SLE patients (Uzrail et al., 2019[190]; Zhou et al., 2019[222]; Guimarães et al., 2017[72]) and that risk loci for IL12RB (You et al., 2015[215]) and genetic variants of IL12B (Paradowska-Gorycka et al., 2016[149]) are associated with SLE.