IFNG and type 1 diabetes mellitus: Additionally, TH17 cells were shown to be diabetogenic after conversion into TH1 cells (Mensah-Brown et al., 2006[126]; Emamaullee et al., 2009[49]; Martin-Orozco et al., 2009[120]; Bending et al., 2009[20]), leading to the assumption that T1D pathogenesis is driven by collaborative immune responses of TH1 cells (IL-12, IFN-γ) and TH17 cells (IL-23, IL-17) (Marwaha et al., 2014[121]).