Furthermore, it has been shown that the IL12A rs485497 polymorphism is associated with pSS and that IL-12p70 serum levels in patients with active disease are higher than in control subjects, whereas serum IL-35 levels were associated with low disease activity, indicating an involvement of the IL-12/IL-35 balance in the pathogenesis of pSS (Fogel et al., 2018[52]). Here, IL12A is linked to peeling skin syndrome.