Consistently, the picture of psoriasis as a TH1-biased disease has been redrawn in the meantime, since TH17 cells were predominantly found in the dermis of psoriatic skin lesions (Yawalkar et al., 2009[212]; Lowes et al., 2008[112]), and IL-22 expression was also increased (Nograles et al., 2009[143]), suggesting that besides TH1 cells, TH17 and TH22 cells have a major influence on disease development. The gene discussed is IL22; the disease is psoriasis.