Multivariate analysis by Albain et al confirmed young age as an independent adverse predictor, finding that cancers in younger patients had significantly higher S-phase fractions and abnormal p53 signaling.22 Younger patients also tend to have factors associated with worse prognosis, including grade 3 histology, lymphovascular invasion, necrosis, and ER negativity.23 The gene discussed is TP53; the disease is cancer.