ERBB2 and breast cancer: Patients with HR-positive/HER2–/LN– tumors with a low-risk Oncotype DX RS (RS <11) are placed in the same prognostic category as patients with T1a-T1b N0 M0 tumors, meaning all tumors meeting these criteria, regardless of size, are downstaged to stage I.9 The low-risk score was lowered to 11 from 18 in the AJCC manual, based on the scale used in the Trial Assigning IndividuaLized Options for Treatment (Rx) (TAILORx) trial in an effort to not undertreat breast cancer.10