Notably, using Cd25Y129H mice allowed us to specifically evaluate the role of IL-2R signaling in Treg cell stability under inflammatory conditions without the intrinsic lymphoproliferative disorder associated with germline depletion of genes involved in the IL-2R signaling machinery, which might explain the diverse results reported in the past.57–59 Here, we showed that reduced CD25 expression caused severe defects in Treg cell stability. Here, IL2RA is linked to lymphoproliferative syndrome.