AHR and infection: This approach leads to expansion of Tregs (both FoxP3 + Tregs and Tr1 cells) that suppress inflammation in EAE.159 Similar observations have been made in other autoimmune diseases, such as type 1 diabetes.127 Within the context of infection or tumors, AHR inhibitors may offer a novel pathway to limit immune evasion,151 with the caveat that AHR may also play a role in limiting immunopathology.