WWTR1 and neoplasm: Recently, many roles for Yes-associated protein (YAP) and TAZ (encoded by WWTR1) as main mediators of the Hippo pathway have been described in (a) regulating organ size [36]; (b) promoting tumor initiation, progression, metastasis [37, 38], and EMT [39]; and (c) reprogramming cancer cells into CSCs [40–42].