The top downregulated TF networks sharing among leukemia patients are RUNX3, KLF4, POU4F1, IKZF2, GTF3A, ATF4, TFDP1, GTF2A2, BCL11B, GFI1, MAZ, HDAC2 and KLF1 (Fig. 3f), with majority being hematopoietic lineage specific, indicating that the healthy hematopoietic process was repressed in those leukemia patients. This evidence concerns the gene POU4F1 and leukemia.