For instance, the most significantly upregulated signatures shared by those leukemia patients are IL-2-STAT5 signaling, inflammation response, angiogenesis, IL-6-JAK-STAT3 signaling, KRAS signaling, allograft rejection and hypoxia, which have been reported in various cancers, indicating these signatures played an important role in cancer progression. Here, STAT3 is linked to leukemia.