RUNX1 and leukemia: The extension and coverage of leukemia cells on hematopoietic tree indicate the heterogeneity of leukemia cells, with long extension or big coverage area indicating high heterogeneity of the leukemia cells, e.g., the AML1, AML4, and AML5 with the highest heterogeneity, while AML2 and 721214 with the lowest heterogeneity due to its shortest extension on hematopoietic tree (Fig. 4d and Supplementary Table S1).