The top downregulated TF networks sharing among leukemia patients are RUNX3, KLF4, POU4F1, IKZF2, GTF3A, ATF4, TFDP1, GTF2A2, BCL11B, GFI1, MAZ, HDAC2 and KLF1 (Fig. 3f), with majority being hematopoietic lineage specific, indicating that the healthy hematopoietic process was repressed in those leukemia patients. The gene discussed is ATF4; the disease is leukemia.