We hypothesized that UL7, miR-US5-1, and miR-UL112-3p could act together to reduce FOXO3a levels and activity at early times postinfection to block the induction of the proapoptotic transcript BCL2L11. As shown in Fig. 5, UL7 is expressed at 2 days after wild-type HCMV infection in four independent donors. The gene discussed is FOXO3; the disease is cytomegalovirus infection.